Science / cells: basic research shows that non-psychotropic cannabinoids cannabidiol are effective as anti-cancer drugs in leukemia
New research has shown that no psychotropic cannabinoids of the cannabis plant could be effective anti-cancer drugs. The anti-cancer properties of THC, the primary psychoactive component of cannabis, are recognized for many years. The study was conducted by the team at the St. George's University in London with leukemia cells. The team of Dr. Wai Liu and his colleagues conducted laboratory tests with a number of cannabinoids, either alone or in combination with the other. Of the studied cannabinoids exhibited any such strong anti-cancer properties as THC. Remarkably, they showed when combined together an increased effect on the cancer cells,.
Dr. Liu said: "These substances are able to affect the development of cancer cells to stop them on their way and prevent them from growing. they can destroy cancer cells In some cases, through the use of specific dosage pattern. In combination with available treatment methods we could discover some highly effective strategies for cancer therapy. "The study examined cannabidiol (CBD), cannabigerol (CBG) and Cannabigevarin (CBGV).
Press release of the St George's University of London. October 14, 2013
Cannabidiol (CBD) may be regarded as the counterpart of tetrahydrocannabinol (THC), since it suppresses the effect. It affects, among others, analgesic, anxiolytic, calming slightly, intraocular pressure-lowering, anti-epileptic and antibiotic.
Hemp and Medicine
In today's medicine, there would be a number of uses for cannabis products. Unfortunately, the intake of natural cannabis products for medical purposes in Central Europe with the exception of Holland is still not legal. Instead, at great expense synthetic cannabinoid compounds, such as dronabinol produced, which can be prescribed under strict medical supervision.
However, many patients believe that smoked cannabis looks much better than the synthetic or semi-synthetic preparations. This is probably due to the unique combination of active ingredients of the cannabis plant, which lacks the synthetic preparations containing only THC. In particular the absence of cannabidiol (CBD) is likely to be detrimental.
Another problem is that many doctors are still a negative attitude about cannabis, or not yet know about the medical benefits of cannabinoids know.
CBD High therapeutic potential
Recently, the American television station CNN has reported a lurid story about the fate of the seven-year-old Charlotte from the state of Colorado. She suffers from a whole rare but cruel form of epilepsy, the Dravet syndrome. The disease begins in the first months of life and is associated with partially over a hundred seizures a day, which are hardly treatable. The disease prevents normal development, a mental disability is the result. Meanwhile, Charlotte has the ability to walk, talk and eat almost entirely lost. Conventional medicine was at her wit's end. They even considered to put the child in an induced coma to allow his body a rest.
The father, meanwhile, sought diligently for a therapy that promises relief from his child - until he came across cannabis. After he had heard that a boy with Dravet syndrome in California was successfully treated with it, he wanted this must have therapy for Charlotte. The effect was striking: the spasms died within hours after.
High therapeutic potential
Rudolf cautery, pharmacist and specialist for cannabis at the University of Bern, reporting on CNN followed closely. About the amazing effect he was less surprised. Since he started in the mid 1990s as a Swiss pioneer of the cannabis research, he was able to observe such effects again. Exciting, however, he found the fact that with such contributions cannabis'm getting acceptable and had been pre-CBD, a constituent of the hemp plant without a"High" effect.
For a long time the research according to cautery has previously focused on THC. However, its application is a problem because of the intoxicating effect. While CBD, as recently discovered, neutralizes this effect, or at least reduced and in addition has a cancer and anti-inflammatory effect. Been known for is its anticonvulsant, anxiolytic, and nausea-relieving effect. "In addition, it has a low toxicity and few side effects," says the pharmacist.
Momentum in research
THC and CBD are among the 66 cannabinoids to the most promising therapeutic agents. Cannabinoids have been used primarily to treat neurological disorders such as multiple sclerosis or epilepsy, against the side effects of chemotherapy or for chronic pain. The discovery of the CBD and its potency was loud cautery of cannabis research a new impetus. So cannabis is always open for the natural remedy new research approaches, such as use in breast cancer, or psychosis.
New impetus is also on the Swiss cannabis "Market": The revision of the Narcotics Act two years ago, the Federal Office of Public Health may recently also grant exemptions from natural cannabis, so far this only synthetic THC was reserved for the loud professionals, however, far less effective is.
This legal niche allows the use of Medizinalcannabis, although cultivation and consumption of THC-containing cannabis, as in most countries is still prohibited. However, even minor, international pharmaceutical companies to mix with this increasingly lucrative market. So soon comes "Sativex" on the Swiss market, inhalation spray on the basis of THC and CBD in the treatment of muscle spasms in multiple sclerosis. The same company has received these days in the U.S., the approval of clinical trials in epilepsy patients with a CBD-containing spray.
CBD, THC and CBG - A closer look at the cannabinoids
Cannabis contains over 480 active ingredients, of which 80 have been found only in cannabis. That's a lot of different variables that affect the body and that's partly the reason why there are always new published scientific research describing new discoveries around cannabis. The compounds 80, which are only found in cannabis are termed cannabinoids. These interact with the receptors in our body, they trigger reactions in our nervous system and brain. Here below is a brief overview of the 8 main cannabinoids found in marijuana.
Tetrahydrocannabinol This is the best known and most abundant cannabinoid in Cannabis, it stands for Δ-9-tetrahydrocannibinol. This cannabinoid is responsible for the main psychoactive effect, which can be experienced in the consumption of cannabis, it stimulates areas of the brain, which causes the release of dopamine - which in turn causes a feeling of euphoria and well-being. THC also has an analgesic effect, it relieves the symptoms of pain and inflammation. Combined, this causes a great feeling of relaxation.
CBD Cannabidiol or CBD abbreviated is, tends to be in terms of quantity the second most abundant cannabinoid in marijuana. It hasa serious impact on the medical field and is the most desirable combination of medical users. It is a non-psychoactive component, probably reduces the effects of THC and regulated. This means that varieties with a lot of CBD next to the THC trigger a frenzy, in which the head is much clearer than eg in the Haze varieties that contain very little CBD. CBD itself has a long list of medical properties. Among the most important things here are the relief of chronic pain, inflammation, migraine, arthritis, cramps and epilepsy and schizophrenia. CBD has also shown properties that act against cancer and with each new benefit further research are constantly being found.
Cannabinol Cannabinol or CBN abbreviated, is an analgesic that ensteht by the degradation of THC by oxidation. It is easy psychoactive and can be found in fresh cannabis plants only in small amounts. Its occurrence can be reduced to a minimum by storing harvested cannabis in a dark, dry place. Tends to the effect of THC the preferred CBN, for CBN is not as effective as THC and may cause fatigue, if it occurs in high concentrations. From it is also known that it reduces anxiety and reduces the intraocular pressure.
Cannabigerol CBG, also known as cannabigerol, is an active ingredient in cannabis, which is known for its antibacterial effect. It was noted in recent research that there are varieties Although traditionally not very common in most cannabis, but that it probably is the "template" or "stem cell" for both THC and CBD. This means that THC and CBD emerge from the CBG. CBG was also found to inhibit the uptake of GABA, resulting in a feeling of relaxation, which is normally associated with the CBD. These findings have spurred new research in this cannabinoid, which could come out that it might also have a greater impact.
THCV Of tetrahydrocannabivarin THCV or abbreviated, it is believed that it is a cannabinoid that attenuates the intensity of the psychoactive effects of THC. Current research is carried out to THCV, suggests that it can be used to treat metabolic disorders and functions as an appetite suppressant.
Cannabichromene Although not much medical research has been performed in this cannabinoid suspected of cannabichromene or abbreviated CBC, it has anti-inflammatory and analgesic effects. Let recent research suggests that it potentially plays a role in cell regeneration in the brain.
Tetrahydrocannabinolicacid THCA is an acid form of THC. It is a raw state in which THC in fresh cannabis plants can be found. Only when cannabis is heated, the THCA is converted to THC. THCA from this raw form, it is believed that there is no active connection.
Similar to THCA, CBDA is the acid form of the CBD. It is currently believed that it has an antiemetic effect (anti-nausea effect), and that it helps to combat breast cancer.However, more research on its medicinal benefits of distress.
The endocannabinoid system
It is likely that you have encountered while reading the comments on cannabis, as the cannabinoids with receptors in our body interact, without really knowing what is to be understood. Well, no more question you, here is our short guide when it comes to this matter.
The network of receptors in our body, also known as the endogenous cannabinoid system is the part that is responsible for maintaining the overall health and it is probably one of the most important physiological systems in our body. This system, which was, after cannabis, the plant, which led to its discovery, named, extending through the whole body. It fulfills a variety of functions, but its main purpose is the maintenance of homeostasis - the regulation and maintenance of a stable environment within the human body.
CANNABIS AND THE ENDOCANNABINOID SYSTEM
Human Nervous System The similarity between the names is the first thing that catches an eye. The reason is that the cannabinoids contained in cannabis, which are extremely similar to that produced naturally by our body - the endocannabinoids. "Endo" is the short form for endogenously, which comes from the Greek "generated inside" produced by the body itself. Outside of a living organism 'cannabinoids found in cannabis only, hence the name.
It was the particular way interact as cannabinoids from the cannabis with our system, which led to the realization that we have our own natural form of cannabinoids. If our bodies are fed cannabinoids, this causes an interaction with the endocannabinoid system, which is why we experience the physiological and psychoactive effects of marijuana. A very simple way of looking at is this: The body produces endocannabinoids to regulate its own system and to modulate and if we bring the cannabinoids from the cannabis, we turn the system into overdrive, as we increase the amount of available cannabinoids.
CB1 AND CB2 RECEPTORS
Receptor The endocannabinoid system consists of various receptors, all of which interact in different ways with the cannabinoids and lead to different results, but all with the same goal in mind - homeostasis. The two most important receptors within this system are known as CB1 and CB2 receptors. CB1 receptors are mainly located in the brain and nervous system, whereas CB2 receptors are part of our immune system. It is the way in which the various cannabinoids in marijuana bind to these receptors and interact with them, which trigger the holistic and profound effects, which we can then feel. It is interacting with our body system because of the manner in which THC, CBD and the many other lesser known cannabinoids - very often to our advantage. That is the reason why cannabis has such far-reaching impact on medical science.
What all this shows is that cannabis grows not only on this planet to make us "high" (although many love to be just that). Amazingly, research has shown that cannabis plants use the cannabinoids in their systems in order to obtain their own healthy growth and promote. It seems that the cannabinoids have a similar function for us, as for the cannabis itself supported by long historical use, a large area of scientific research seems the medical potential of cannabis in a variety of diseases, such as epilepsy, diabetes, and arthritis affirm. It is also used to alleviate pain and reduce inflammation.
But for slander politicians and greedy companies who use cannabis have pushed a bad reputation, much needed research was suppressed. Fortunately, this negative attitude with more and more sound, scientific researches that investigate the properties of cannabinoids and what benefits they have for the body, then slowly broken down. As a result, begin now to many countries, including the U.S., as the marijuana to see what it really is. recent research has shown that cannabinoids can act as a preventive agent to treat cancer, and may help repair brain damage caused by alcohol? And that is only scratching the surface, because scientists are constantly finding new uses and effects - we should be prepared for a pretty exciting time!
Traditionally, the THC content is the sole indicator of strength and quality of a variety, but that's changing, while the benefits of the other cannabinoids, and in particular the CBD are scientifically recognized. THC is the cannabinoid that is largely responsible for the psychoactive effects of cannabis and is at recreational users because of its intoxicating properties still the most sought-after connection. For this reason, most breeders have focused on increasing the THC content, but neglected other cannabinoids such as CBD.
With more and more scientific evidence supporting the medicinal effects of cannabis, we see not only a revival of the legal and socially acceptable use of medical cannabis, but also a shift of focus to other cannabinoids. THC has proved that it has its own medicinal qualities, but it is the CBD, which has moved because of its wide range of medical qualities into the spotlight. Especially the lack of a psychoactive effect makes CBD attractive for a variety of applications because it was administered successfully children without it caused a frenzy. As a result, produce cannabis breeders now many new varieties that have high CBD values.
While the mass media CBD pick up on stories of how the little girl Charlotte, who beat her epilepsy with a CBD-rich variety, the consciousness spread all over the potent medicinal qualities of this cannabinoid. The legalization of cannabis for medical and recreational use in a number of U.S. states has the availability of CBD-rich varieties increased even further. However, not all medical users lucky enough to be able to buy cannabis in pharmacies legal and illegal cannabis from the road is not suitable for medical use. Therefore, many take it into their own hands and build their own supply, from which they produce their own drugs such as tinctures and concentrates.
CBD is the abbreviation for cannabidiol, the second most important after the THC and cannabinoid in the cannabis plant. If you look at the cannabinoid content of a variety, it is quite common to find a THC content of about 12-20 percent, where everything is 20 or more, as is very highly regarded. This is not the case in the CBD - it is rare that such high values of it are to be found; each CBD content, which is 4 percent or more is regarded as a CBD-rich species. Although 1% CBD is already much better than nothing, but in recent years, varieties with 18% CBD have emerged, although they are still rather difficult to come by. Commercially available CBD-rich varieties contain between 8-12% CBD.
WHAT CAUSES CBD?
Initially it was always thought that CBD would modulate and attenuate some of the effects of THC - which was a good reason for growers to neglect it. Recent studies have shown, however, that it is actually the CBD, which potentially has the most medicinal value. It is true that CBD changed the way how THC interacts with our body, but not necessarily negative. It counteracts some of the unwanted side effects that may be associated with high THC doses, and prolong its effects.
Used alone, it has been shown in the CBD that it is applicable and useful in a variety of diseases, ailments and problems. Research has shown that CBD showed promising results in the treatment of multiple sclerosis, Crohn's disease, Alzheimer's disease,Parkinson's disease, PTSD,and epilepsy, CBD is a component of cannabis that may help the patient to cope with chronic pain, cramps, and arthritis.
Again, it should be noted that CBD, unlike THC, is not psychoactive. Therefore, and tinctures and extracts are used to treat children suffering from debilitating illnesses - such as the above-mentioned case of Charlotte, a cannabis takes tincture, which is made from the aptly called CBD-rich variety "Charlotte's Web", to fight their seizures. Before taking cannabis Charlotte had 1,200 seizures per month - now she has about 3 and shows a balanced behavior.
In addition, CBD has no negative side effects, does not harm the body or mind, is not addictive and can not be overdosed
Cannabis Research: Alzheimer’s Disease
Alzheimer’s is a physical disease of the brain and one of the most common causes of dementia. It causes the formation of “extracellular” and “fibrillar” deposits, which means that cells die in the brain. This progressive disorder causes slowly more and more brain damage, in which the mental condition of the patient gradually deteriorated. The symptoms of Alzheimer’s disease are:
Memory Loss – Is easily confused and finds it difficult to remember names, places, people and recent events.
Mood swings – Can easily be angry, anxious or frustrated as a result of increasing memory loss.
Withdrawal – Pulls emotionally still further back, the more difficult the communication.
Cannabis & Alzheimer’s studies:
1) prevention of Alzheimer’s disease pathology by cannabinoids: neuroprotection by blockade of microglial activation (Prevention of Alzheimer’s Disease Pathology by Cannabinoids: Neuroprotection Mediated by Blockade of Microglial Activation – 2005)
Cannabinoids are known to act as neuroprotective agents in the brain. This prompted the researchers, the function of the cannabinoid receptors and the possible protective properties that have the cannabinoids in marijuana to judge in Alzheimer’s patients. They found that the cannabinoid receptors play a role in the illness and that prevent the cannabinoids that the neurodegenerative process is taking place. Published in the “Journal of Neuroscience.”
2) Marijuana slows decay by Alzheimer’s disease (Marijuana Slows Alzheimer’s Decline – 2005)
Studies of the Hebrew University in Jerusalem, who were eye aimed to find out whether the non-psychedelic cannabinoids in cannabis may help in the treatment of Alzheimer’s disease. They found positive results in mice, which indicated that the use of cannabis could slow down the degeneration of memory. Published by the “Israel National News”.
3) A molecular link between the active component of marijuana and Alzheimer’s disease pathology (A Molecular Link Between The Active Component of Marijuana and Alzheimer’s Disease Pathology – 2006)
This research aimed to find out what role THC, in contrast to the non-psychoactive cannabinoids, could play in the treatment of Alzheimer’s disease. It has been found that THC inhibits effectively the AB Group, the principal pathological markers of Alzheimer’s disease. They took together that the effect that had THC, was even better than that of prescription drugs that were at the time available. Published in “Molecular Pharmaceuticals.”