CBD The less well-known cannabinoid Posted on 20 Dec 07:54

 CBD The less well-known cannabinoid

In the present situation with the rapidly spreading cannabis culture is started all over the world with ground-breaking scientific research and we learn that there is about the constituents of this magical plant to discover a lot more. One of the greatest discoveries made by modern research was the second most concentrated cannabinoid: cannabidiol, abbreviated CBD. THC and CBD are the naturally far the most abundant cannabinoids of which represents on average 12-25% THC, CBD 1-4%. If only a quarter of that is true, what scientists report on CBD, this medical breakthrough may also be a significant impact on modern natural medicine have as the discovery of antibiotics.

CBD is the THC as a brother or sister because she, like all siblings times work in harmony to fight another day together. Unlike cannabidiol THC is a psychoactive compound (ie, it affects the brain functions by acting on the central nervous system, which can lead to mood swings, changes in behavior, the perception and perception), and the effects get the smokers among consumers of be felt most clearly cannabis. The high is responsible for the feeling of relaxation that intense sensual feelings, and of course the inevitable "munching" because you get a craving for all kinds of eatables. It can also be used for medical treatment of many symptoms: mild to moderate pain, insomnia, depression, nausea and loss of appetite (just to name a few). For some people, however, THC could trigger anxiety or paranoia, often associated with the feeling that time slows down, which is not real, of course, the case.

CBD is regarded as a non-psychoactive cannabinoid, although it seems to have certain psychoactive effects. It provides a high that has a calming effect and is responsible for the relief - the medicinal effect, which most people expect. The medical applications of CBD surpass all other cannabinoids that we know: effective prevention or treatment of inflammation and nausea, diabetes, alcoholism, post-traumatic stress disorder (PTSD), schizophrenia, rheumatoid arthritis, epilepsy, diseases of the coronary arteries - it has an anti-psychotic, against fears and even as a pain killer against muscle cramps or nerve pain, the pharmaceutical with any conventional medicine, and even each, are more difficult to treat.

While both the THC and the cannabinoid CBD taken in itself possess many healing promoting properties, their effect "collective power" is (just as it comes from the marijuana plant) is much more impressive. On the side of the THC-CBD molecules can neutralize some of the fears that THC also can trigger and CBD also carries more than THC for alleviating various types of pain at. Both are united in one single plant nature makes the best doctor, because they are far more effective when they are administered together, especially in persons with a variety of symptoms. CBD appears to counteract also the provocative effects of THC by delaying the onset of high and simultaneously causes it twice last as long. If auszubleiben the effect of smoking seems and we already fear that the flowers could have come from any other ominous green, ... but then, all of a sudden ... WHAM! ... It comes out of nowhere and hits you like a ton of bricks. Although marijuana has different effects on people, you have these opposite effects already experienced determined.

In mammals, birds and fish are found endocannabinoids compounds that are produced by their bodies; they are basically "naturally" produced THC compounds, which are called anandamide. Technically, an anandamide (Ananda = bliss in Sanskrit + = amide chemical substance) is a naturally occurring neurotransmittierende compound that circulates in our bodies. Both THC and anandamide acts on cannabinoid receptors are located on cells everywhere in our bodies and have similar effects on pain, appetite and memory. Receptors are nothing else than in cells embedded door opener proteins, the chemical signals of off-molecules lead into the cell and instruct the cells to do something - something like air traffic controllers for our cells, this communication only takes place when a molecule or compound binds to it. A molecule which binds to a receptor is called a ligand. Receptors are very specific when it comes to what can bind to them, and only certain compounds dock to the respective receptor types. It works like a lock and key, just open the appropriate key the respective doors. When the doors open, then the way is clear, and in the case of receptors is the driveway for an instructional signal. Many different kinds of receptors may be located in a single cell are provided for communicating with various chemical compounds.

Cannabinoids can act only on us because our bodies contain these receptors, which are created to bind specific cannabinoid molecules. Human brains have in fact more cannabinoid receptors than any other G-protein coupled receptor! Our cells contain a large number of these receptors, which bind specifically to the THC. Apart from that our bodies produce their own form of "natural THC" (anandamide) - even when the concentration is very low - so that the fact can make sense to explain why people are attracted to this plant so. On the way, how our bodies utilize cannabinoids is nothing unnatural - and marijuana has proven to be a very effective natural medicine that should be applied to patients who need it, is available.

So far, only two cannabinoid receptors in the human body known to bind with THC: the CB1 receptors, which are found in the brain and central nervous system, and CB2 receptors, which are distributed all over the body, but mainly in the immune system . In addition to cannabinoids in cannabis (which are most potent of course) and those that our body produces naturally, there are many other substances, such as Echinacea, saffron root, black pepper, cocoa, etc., affect the minutely our internal endocannabinoid system. These and some other substances, it has been found, also bind to just these cannabinoid receptors.

However, cannabidiol or CBD has no strong tendency to bond two of the known cannabinoid receptors. Instead, it has an inhibitory effect on the enzyme FAAH ("fatty acid amide hydrolase"), the enzyme responsible for the break and destruction of Anandamiden. This suppressive effect of CBD means that more Anandamide remain for prolonged periods of time in the system. Anandamide preferentially as THC the CB1 receptor, therefore it leaves less "breaches" of the process of THC binding to these receptors and in turn less effect to.
While CBD does not bind to CB1 or CB2 happy, it was shown that it interacts with other receptors to allow the medical effects. There are some G-protein receptors in the central and peripheral nervous systems that interact with the CBD. Then there's the TRPV-1 (short for "transient receptor potential cation channel subfamily V"), which responds to it. The TRPV-1 receptor - he is also activated by capsaicin, the "burning" substance contained in chillies - is known is that it transfers the perception of pain, inflammation and body temperature; most likely you will have felt some of these effects while eating a very sharp pepper.

The 5-HT receptor family playing in our bodies respect anxiety an important role, the receptors are activated by the neurotransmitter serotonin. These receptors trigger via chemical messengers from reactions that are either excitatory or inhibitory - it depends on the context of the chemical bond. The 5-HT1A serotonin receptor belongs to the family of receptors that binds with CBD. And once it has been activated by the CBD, it exerts the intense anti-depressive effects of cannabinoids, which then expand to other medical functions, the CBD holds, because this receptor to still working in a wide range of anxiety, addiction, appetite , sleep, pain perception, nausea, vomiting, etc., and the associated processes includes. This is done by activating an inhibitory response, which slows down the transmission of signals. Other drugs such as LSD, mushrooms and hallucinogens activate the other hand, another 5-HT receptor that elicits an excitatory response.

CBD spread some of his fears degradative effects through the activation of so-called adenosine receptors. They regulate the function of coronary vessels, myocardial oxygen consumption, coronary blood flow and combat many anxiety symptoms: muscle tension, stitches in the chest, shortness of breath, etc. These receptors in the brain are important regulators of other neurotransmitters such as dopamine and glutamate. Dopamine is not only responsible for triggering pleasant feelings, but can also affect sleep, mood, memory, attention and voluntary movement. Other drugs such as cocaine and methamphetamine act by also enhance the effects of dopamine receptors, but to a far greater extent. While THC transiently increased dopamine levels, it does not apply to the CBD; it was found only sporadically in experiments which were carried out on mice and rats, and worked mostly as an inhibitor. It must further research be done to figure out why that is and why it only happens randomly. Perhaps there is a connection with one of the other 83 cannabinoids, of which we know so little.

It has been proven that by itself both CBD and THC fight cancer, but together develop synergetic effect. We need more clinical research to determine exactly to what features they have, if they cooperate in the form of cannabis. Due to the unfortunate fact that, at present, the cultivation and use of cannabis is still mostly restricted on a worldwide or is prohibited, there is a lack of necessary funds and resources of governments and organizations to enable such research. While distributed some research at universities and research colleges are all over the globe performed together provide enough strong indications of a possible hot lead in the relationship cannabis / cancer, missing up to now but the unique results. This potential track closes another as GPR55 identified G protein-coupled receptor a, which is sometimes called the "orphan receptor" because he has not yet been assigned to scientifically a family of receptors, although many researchers believe that it is a third cannabinoid receptor acts. GPR55er are mainly found throughout the brain, concentrated in the cerebellum and around it, and it is used to regulate bone density and blood pressure. The amplified signals of a hyperactive GPR55 receptor, for example, indicate osteoporosis. The receptor support, the behavior of the osteoclastic cell and osteoclast is responsible for bone resorption - a process that is degraded in the bone and calcium is transferred from the bone into the blood, which have been weakened. If this receptor is activated, it also promotes the rapid growth (proliferation) of tumor cells and is associated with many types of cancer. Some studies have shown that blocking the CBD of GPR55 outgoing signals, thereby reducing both the proliferation of cancer cells as well as bone resorption and exerts its anti-cancer effects.

For most tests with illicit cannabis is about the THC, whereas the CBD itself is quite LEGAL and available in many forms in most countries. Unfortunately, it does not have the same effects as with the combinations that are to be found in cannabis, but even on its own it can perform medical miracles. University studies have shown in mice that it has enormous effects: a drop in induced rheumatoid arthritis inflammation by 50%, even caused by infarct tissue death (necrosis) has been reduced by 65% ​​when it was administered immediately after the heart attack.

The high CBD-rich plants (or food) is usually felt more strongly in the body, the high-effect of THC more in mind, but these effects can vary depending on the CBD / THC ratio. The differences can be perceived quite simple and clear when one compares the feeling after smoking of cannabis use in the test consume an edible Cannabisleckerbissens. There are several reasons. One of them is: In the leaves of the plant contain more CBD than in the flowers and most of us keep the flowers in order to smoke later and take the leaf debris for baking. Another reason: If THC heated, it begins at a temperature between 150 and 157 ° C burn off, during the cannabinoid is CBD opponent, the threshold which is necessary for burning, 160-180 degrees. I do not know how it is with you, but I do not know many brownie recipes with a baking temperature of less than 150 ° C. If you are not privy to the knowledge, adjust baking temperature and time correctly, then you will have something to do with CBD-filled treats that they devour. The stems also contain more CBD than the flowers and therefore it is worthwhile to use the whole plant.

Contrary to what some people believe, a plant can not be made a CBD-rich plant when the genetic makeup for it does not exist. The ratios of THC, CBD and all other cannabinoids are genetically predetermined. The fact is that there are very few plants that produce abundant CBD (from a high percentage of people talk from 4%); which is really a shame and a direct result of years of crossbreeding to a high THC content.

Of the currently available stock of seeds is only 25-30%, the CBD-rich (ie,> 4%) have the potential varieties. These potential varieties produce a number of seeds, which show the different phenotypes of seedlings, both CBD-rich and THC-rich plants in each generation. On average, one developed by four derived from a CBD-rich cannabis plant seeds to a seedling of the CBD-rich phenotype. In rare cases it can be two times of four, so the chance CBD dominant seedlings is between 25 and 50%. The only easy way to multiply a CBD-rich varieties strong, is to find one of these dominant phenotypes and to make this plant from the parent plant to remove from their clones; all clones have exactly the same CBD / THC ratio as the parent or donor plant.